Doctor De Soto, a mouse dentist, copes with the toothaches of various animals except those who have a taste for mice, until the day a fox comes to him in great pain.
Sophie does not enjoy energetic, assertive Wendell's weekend visit until the very end, when she learns to assert herself and finds out Wendell can be fun to play with after all.
Devoted to making lists about everything in his life, Wallace the mouse discovers the joys of spontaneity and adventure when he becomes friends with his neighbor Albert.
To get the "ratoncitos," little mice, who have moved into the barrio to come to his house, Chato the cat prepares all kinds of good food: fajitas, frijoles, salsa, enchiladas, and more.